I'm just famiilarizing myself with Studio 14.10
After logging on in Tera mode as an admin user, when choosing Administer from the Tools Menu,
Roles and Profiles are greyed out. (Create,Modify and Security menus also have some selections greyed out)
What have I missed?
The menu and toolbar items are enabled based on what you have selected in the Data Source Explorer, as that is the object they will act on. Administering Roles and Profiles is enabled for the Database node at the top so select the Database and it should be enabled or provided as a context menu for the Database object in the DSE (right click). You can also display the objects in the Teradata View and the approprate toolbar actions will appear.